OECD GUIDELINE FOR THE TESTING OF CHEMICALS Acute Oral Toxicity: Up-and-Down Procedure
ثبت نشده
چکیده
1. The proposal for this guideline was submitted by the United States. The concept of the upand-down testing approach was first described by Dixon and Mood (1)(2). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (3). There exist several variations of the up-and-down experimental design for estimating an LD50. This guideline is based on the procedure of Bruce as adopted by ASTM in 1987 (4).
منابع مشابه
OECD GUIDELINE FOR TESTING OF CHEMICALS Proposal for a New DRAFT GUIDELINE 434: Acute Dermal Toxicity – Fixed Dose Procedure
1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress and animal welfare considerations. The original acute Dermal Toxicity Guideline TG 402 (1) was adopted in 1987. Development of a dermal Fixed Dose Procedure (FDP) was considered appropriate, following adoption of the revised Oral FDP, OECD Guideline 420 (2) and deletion of OECD Guidelin...
متن کاملOecd Guidelines for the Testing of Chemicals
1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of...
متن کاملOecd Guideline for Testing of Chemicals
1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of...
متن کاملAcute and sub-chronic toxicological evaluation of ethanol extract of Solanum trilobatum Linn.
Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...
متن کاملAcute and Subchronic Toxicity Assessment of Aerial Parts of Ferula persica in Female Mice
Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 1998